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In fact, the high expression of glycogen synthase-1 in RA-FLSs can lead to the excessive accumulation of glycogen and inhibit AMPK expression, leading to the high expression of matrix metallopeptidase (MMP)-1, MMP-9, IL-6, and CCL-2, along with increased proliferation and migration of FLSs

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Moreover, the activation of Sirtuin-1 can promote Parkin to translocate from cytosol into OMM, while inhibition of Sirtuin-1 reverses these effects ( 3.3.1.1 Polydatin Polydatin, a resveratrol glycoside isolated from traditional Chinese herb, Polygonum cuspidatum ( via the activation of Sirtuin-1

Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKII-GSK3 interactions