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The copper coordination gives the complex its characteristic deep-blue color

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Thus, discovered that valproic acid increased the activity of capecitabine in breast cancer cells after suppressing histone deacetylase 3

(Alternative mechanisms of activation of the N -hydroxylamine may happen in vivo : sulfation or acetylation of the hydroxylamine would give N-O-sulfate or N-O-acetyl adducts that are excellent leaving groups, the elimination of which might lead to the generation of highly reactive nitrenium or carbonium ions, but these have not been reported as yet)

Prodrugs are conjugated to RNA nanoparticles via efficient click chemistry, creating an ester linker that is cleaved by esterases in tumor tissues or cells, allowing the prodrugs to return back to their original structures and chemistry upon delivery and release, minimizing toxicity