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J Mol Endocrinol (2017) 58:R7385
Quick Answer: You can activate GLP-1 hormone naturally by consuming high-fibre foods, lean proteins, healthy fats, engaging in regular physical activity, maintaining adequate sleep, and supporting gut microbiome health
The weight loss achieved with GLP-1 medications now approaches what was previously only achievable through surgical intervention, though the most severe cases may still benefit from combined approaches
Drug interactions: Orforglipron's CYP3A-mediated metabolism raises the potential for drug-drug interactions with strong CYP3A inhibitors and inducers