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Although biologically notable, transcriptomic shifts do not necessarily indicate tissue rejuvenation or restored function in humans

Therefore, it requires more efforts on developing other alternative targeting strategies based on mutated genes in MM such as splicesome complex components, telomerase, and DNA repair pathway

The glutamate that results from ornithine and proline catabolism can then be converted to 2-oxoglutarate (-ketoglutarate) in a transamination reaction