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Dapiglutide is one of the first agents in this emerging generation of weight-loss drugs

Studies have continually demonstrated a strong link between a dietary reliance on cyanogenic cassava coupled with general malnutrition, however, these risk factors are present in many regions of sub-Saharan Africa where konzo does not occur 5,24,25

Statistics from the phase 3 SURMOUNT study, which recruited over 5,000 adults globally, demonstrated a pronounced reduction in body weight in the tirzepatide-treated group compared to placebo (NCT04184622)

This polypharmacy consideration is particularly relevant for GLP-1 users managing multiple health conditions