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Another interesting point from the (Koeth et al, 2013) paper, they found that vegans did not convert carnitine into TMAO, and they realised that the breakdown of carnitine to TMAO was mediated by gut bacteria that vegans didnt have
High-fat diet (HFD) feeding and obesity induced a shift in the microbiota from Bacteroides to Firmicutes in mice, and the abundance of certain Firmicutes species was positively correlated with energy intake and plasma C-reactive protein (CRP) levels ( Studies demonstrate that gut microbiota and their metabolites influence the brain through direct vagal signaling or indirect immune-neuroendocrine pathways (73)
