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Per the American Diabetes Association (ADA) Standards of Care in Diabetes2026, diagnosis is confirmed by one of four criteria: fasting plasma glucose 126 mg/dL, 2-hour plasma glucose 200 mg/dL during a 75-g OGTT, A1C 6.5% (using an FDA-approved CLIA-certified method), or a random plasma glucose 200 mg/dL in a patient with classic hyperglycemia symptoms

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73 Quantitative flux analysis reveals depletion of either MTHFD2 or MTHFD1 results in decreased cellular NADPH/NADP + and GSH/GSSG ratios and increased cell sensitivity to oxidative stress

Yet an increasing body of research suggests that metabolic health is deeply connected to the condition of the gastrointestinal tract

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