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Caffeine regulated four inflammation-related signaling pathways (Toll-like receptor signaling, JAK-STAT signaling, NF-kappa B signaling, and Th17 cell differentiation) and seven metabolic signaling pathways (glutathione metabolism, PPAR signaling, phagosome, PI3K-Akt signaling, insulin signaling, fructose and mannose metabolism, and AMPK signaling) that were not regulated by EGCG (Figure 8A, left side of orange box)

This effect has been observed in various tissues, like tendons, muscles, and skin

It is unstable, photo-sensitive and irritating at high concentrations

Getting adequate protein and micronutrients removes a common bottleneck in the collagen production pathway