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Autoimmun Rev (2021) 20(2):102736

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Side effects improve over time Second Natures published research found that side effects with semaglutide decreased substantially over 12 months: 4 Nausea dropped from 31.5% at month 1 to 3.1% by month 12 Fatigue dropped from 24.6% at month 1 to 3.1% by month 12 By month 12, 67.7% of semaglutide users reported no side effects Long-term real-world side-effect tracking data for liraglutide are limited, though clinical trials showed a similar pattern of improvement over time

And the guidelines should have widespread ramifications for policy decisions in countries where the drugs have not yet been approved

Insurance companies typically dont cover the costs for drugs prescribed off-label, or they may require a prior authorization