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Supplementing glutathione before depletion occurs theoretically allows the liver to maintain acetaldehyde clearance without the oxidative stress that compounds hangover severity

People taking metformin, the common diabetes drug, are known to develop B12 deficiency as well, and people who avoid animal products can be deficient

Tirzepatide, a dual GLP-1/GIP receptor agonist has been approved for glycaemic control in type 2 diabetes as well as for obesity management leading in up to 22.5% WL in phase 3 obesity trials