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Plus, a 2020 meta-analysis of 12 studies found that berberine intake modestly but significantly decreased study participants body weight, body mass index (BMI), waist circumference, and concentrations of C-reactive protein (a protein produced in the liver in response to inflammation in the body)
It is postulated that its major role in adult brain would be translocation of acetyl moieties from mitochondria into the cytoplasm for acetylcholine synthesis
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Together, they address four of the five major systems disrupted in mood disorders: neurotransmitter balance, neuroinflammation, BDNF deficits, and HPA axis function
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