kidney issues with tirzepatide and Disease: Safety Guide Interplay of Chronic Kidney Disease

The breakdown of weight lost in the apitegromab group was approximately 85% from fat and 15% from lean mass, compared with 70% from fat and 30% from lean mass in the placebo group

The presence of GLP-1 receptors in testicular tissue and evidence of direct, weight-loss-independent effects on sperm function raises the possibility that GLP-1 drugs may act on male reproductive biology through two distinct mechanisms simultaneously: one systemic (through metabolic improvement) and one local (through direct testicular signaling)

In the meta-analysis, SGLT2 inhibitors significantly reduced major adverse cardiovascular events (MACE), hospitalization for heart failure (HF) plus CV death, and progression of CKD by 11%, 23% and 33%, respectively, compared to placebo

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Refaat M, El-Damhougy K, Sadiq A, Attia M, Mabrouk M (2013) Desensitization by sublingual immunotherapy for crustacean allergy