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Because a major physiologic function of GSH is to provide cells with a reducing environment and to destroy the reactive oxygen compounds and free radicals formed in metabolism, organs that have low concentrations of other antioxidants (such as catalase and superoxide dismutase) are thought to be more dependent on GSH for detoxification of reactive oxygen species than are organs that have alternative antioxidants
Resmetirom's mechanisms of action include increased fatty acid -oxidation, reduced hepatic de novo lipogenesis, and enhanced clearance of plasma atherogenic lipoproteins, thereby targeting key pathways involved in MASH development (Petta et al., 2024[60])
Liraglutide is a GLP-1RA (glucagon-like peptide-1 receptor agonist) that can reduce appetite and food cravings, increase satiety, and prevent overeating
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