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Table 1: Examples of potential risks during drug-device integration, contributing risk factors and potential mitigations

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Gallbladder and pancreatic risks : The Wegovy SmPC highlights increased risks of gallbladder disease (cholelithiasis, cholecystitis) and pancreatitis

These findings suggest that vitamin D may contribute to venous protection by enhancing NO bioavailability through eNOS upregulation while simultaneously reducing the inflammation-associated NO production via iNOS suppression