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Lee WC, Diao L, Wang J, Zhang J, Roarty E, Chow W, Fujimoto J, Behrens C, Cascone T, Peng W, Kalhor N, Moran C, Johnson FM, William Jr WN, Swisher SG , Heymach J, Wistuba II, Futreal A, Zhang J

Zhou K, Wang S, Xu L, Li H, Wang Y, Qiu Z, et al

doi: 10.1152/ajpgi.1995.269.4.G467

In 1957, Jean Stern converted the blood glucose-lowering potential of metformin in therapy for T2DM: he observed that, in subjects with maturity-onset diabetes, metformin could replace or reduce the need for insulin without the occurrence of frank hypoglycemia [19,20,21,22,23]