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Environmental factors such as pollution, ultraviolet radiation, and exposure to mutagenic and carcinogenic agents can damage body cells by generating reactive oxygen species (ROS), which leads to oxidative stress

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A significant increased risk of PD was observed in women who had the CYP1A2 polymorphism, whereas NAT2, ESR1, and ESR2 had marginal effects on PD risk (Palacios et al., 2010)

1.2 Ghrelins integration into GH regulation The discovery of ghrelin as a potent GH secretagogue significantly advanced our understanding of GH regulation, previously viewed through the simplified GHRH-SST paradigm