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Data Animal Data In a combined fertility and embryofetal development study in rats, subcutaneous doses of 0.01, 0.03 and 0.09 mg/kg/day (0.04-, 0.1-, and 0.4-fold the MRHD) were administered to males for 4 weeks prior to and throughout mating and to females for 2 weeks prior to mating, and throughout organogenesis to Gestation Day 17

In separate clinical trials of non-surgical populations, tirzepatide (SURMOUNT program) and semaglutide (STEP trials) have both demonstrated significant weight loss efficacy

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