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Mitophagy, in particular, serves as a key mechanism for maintaining metabolic homeostasis by selectively removing damaged mitochondria and limiting the accumulation of ROS [47].In CRC, the PINK1Parkin-mediated mitophagy pathway and Drp1-driven mitochondrial fission have been shown to act in concert to preserve mitochondrial quality under chemotherapeutic stress [48]

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International Journal of Molecular Sciences , 25(5), 2952