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It also helps in inhibiting Bax/Bak and caspase-3, which are pro-apoptotic proteins, thereby inhibiting apoptosis while also upregulating the activity of SOD and GPx through the Nrf2/ARE pathways (192)

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ii) doxorubicin also contains the hydroquinone moiety as part of its chemical structure, allowing auto-oxidation to be used as a parameterisation method for a potential redox cycle