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These effects can contribute to gradual, sustainable results when combined with consistent lifestyle habits

The MR-Egger intercept method identified horizontal pleiotropy between serum Ca levels and GD (MR-Egger intercept = 0.010, p = 0.030), with no similar findings for other micronutrients

"It's not a great drug," says McCullough

In a RDP clinical trial with 200 peri-menopausal women, a significant decrease of LDL cholesterol by 9.9% and a significant increase of HDL cholesterol by 4.6% were observed after six months of Pycnogenol (200 mg) supplementation ( supplementation by 3.9 and 3.5%, respectively, while after placebo systolic and diastolic blood pressures were decreased by 1.7 and 1%, respectively