In human 28% microglia renew per year, and microglial cells are on average 4.2 years old (Ru et al., 2017)
Best practices: Store reconstituted blends at 2-8C, use within 2-4 weeks, protect from light and oxygen, and discard if you observe color changes or precipitation.
Common Symptoms May Include: Persistent fatigue or weakness Brain fog or difficulty concentrating Rapid heartbeat Shortness of breath with exertion Mood changes Numbness or tingling (advanced cases) Individuals at Higher Risk: Vegetarians and vegans Patients with celiac disease or other malabsorption disorders Those taking acid-reducing medications (PPIs, H2 blockers) Long-term oral contraceptive users Individuals with heavy alcohol use Patients with pernicious anemia Individuals with chronic gastrointestinal conditions Deficiency can negatively impact metabolism, neurologic function, and immune health if left unaddressed
Table 1 : The enriched pathways depicted in Figure 8
Associations between dietary intake of mitochondria-related nutrients with the risk of migraine: a prospective study of 202,656 participants