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doi: 10.1016/0014-4835(73)90069-9

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While efficacy for motor symptoms was limited, the safety data helped establish the dose range that would later be used in obesity trials

Kidney health is another area of concern

Key clinical trials supporting GLP-1 use include: Large, randomized weight-loss trials demonstrate GLP-1 RA superiority for sustained weight loss and metabolic gains, with fertility endpoints as secondary endpoints in subgroups