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FOXO4-DRI vs nearby senolytics Option FOXO4-DRI Type D-retro-inverso peptide Human trial stage None (preclinical only) Option Dasatinib + Quercetin (D+Q) Type Small-molecule drug + flavonoid Human trial stage Early human trials (e.g., Alzheimer's) Option Navitoclax Type BCL-2 family inhibitor Human trial stage Later-stage trials (e.g., myelofibrosis) D+Q and navitoclax are further along in humans but can affect healthy cells (e.g., low platelets)

Additionally, in the DHE staining results, we observed that FOXO4-DRI treatment effectively reduced the ROS levels in the aorta of aged mice (Figure 2F)

5 Adverse effects Progoitrin and indole glucosinolates in Brassica vegetables can degrade to goitrin in the presence of myrosinase, potentially decreasing thyroid hormone production (144146)

Although it can affect any joint, most of the OA burden is attributed to knee, hip, hand, and spine OA [2]

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