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Overall, microbially produced metabolites act as potent CNS regulators, either by modulating the vagus signaling and systemic immunity or by directly crossing the BBB (Deng et al., 2024)

Importantly, by immunohistochemical (IHC) staining of xenograft tumor tissues, we found that knocking down ACTL6A expression significantly decreased the level of Ki67, a proliferation marker, and increased that of 4-hydroxy-2-noneal (4-HNE) 45 , a lipid peroxidation marker (Fig

DISCUSSION By combining previous models and making a few parameter changes, we have created a new model of glutathione metabolism that we have used to investigate sexual dimorphism in the glutathione pathway in the liver

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