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Less Common or Rare Ipamorelin Side Effects While less frequent, some individuals may experience: Water Retention: Mild fluid retention or puffiness, particularly in the hands or ankles, can occur but is usually temporary

So far it has been working well

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Monitoring Report: GLP-1 RA Prescribing Trends December 2025 Data | medRxiv

A small percentage of patients may find that Semaglutide produces only a mild reduction in appetite, even after reaching the highest therapeutic doses