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References Richa, S., Fahed, M., Khoury, E

doi: 10.1016/j.pcl.2007.06.001

A randomized, double-blind, positive-controlled, prospective, dose-response clinical study to evaluate the efficacy and tolerability of an aqueous extract of Terminalia bellerica in lowering uric acid and creatinine levels in chronic kidney disease subjects with hyperuricemia

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The up-regulation of TNF-, interleukin (IL)-1, IL-5, IL-6, IL-7, and the chemokines IL-8, monocyte chemotactic protein (MCP)-1, MCP-2, GRO, MIG 26,68 indicate that endplate facture triggers a sterile immune response