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The authors found that after non-surgical periodontal treatment, 8-OhdG concentration in GCF and saliva decreased significantly in both periodontitis groups (however, it was still higher in the smoking group compared to non-smokers), while the content of 4-HNE and GPx enzyme activity in GCF and saliva did not change significantly after the treatment in any of the study groups

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In some cases, patients are bound to face problems of skin rashes or even skin irritation at the area of injection

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10.1002/acn3.270 [DOI] [PMC free article] [PubMed] [Google Scholar] 40.Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, et al