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along with the DBD, contains a ligand dependent nuclear localization signal [62] E ) Ligand binding domain (LBD) containing activation function 2 (AF-2), responsible for agonist induced activity (activity in the presence of bound agonist) AF-2 binds either the N-terminal FXXFL motif intramolecularly or coactivator proteins (containing the LXXLL or preferably FXXFL motifs) [58] A ligand dependent nuclear export signal [63] F ) C-terminal domain Splice variants [edit] AR-V7 is an androgen receptor splice variant that can be detected in circulating tumor cells of metastatic prostate cancer patients [64] [65] and is predictive of resistance to some drugs (caused by missing Ligand-binding domain in this splice variant)