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These changes confirm elevated levels of oxidative stress in CK-stressed plants, consistent with previous findings of elevated H 2 O 2 accumulation and modest increases in enzymatic antioxidants such as SOD, CAT, and APX

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Additionally, no new nanomedicines have been approved by the Food and Drug Administration (FDA) or European Medicines Agency (EMA) for RA between 2023 and 2025, highlighting significant gaps in translating laboratory innovations into clinical practice (54)

This sustained exposure ensures prolonged and stable activation of AMY receptors, a critical feature for studies investigating chronic metabolic regulation in animal models