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Systemic effects show more variability
Vicky Belo
Moreover, such a small molecule could serve as a tool compound to interrogate the function of the ADP-ribosyltransferase tankyrase, which is proposed to expel TRF1 from shelterin, thereby promoting telomere extension 18,19,20,21
Garca-Beccaria and coworkers identified two small molecules from a phenotypic screen that decreased TRF1 nuclear localisation, although it is not known whether these bind TRF1 directly 1
aeruginosa ( Figure 6 ) and viability by scavenging ROS and free radicals directly (electron donation through the thiol moiety) or indirectly via GRed (this study) and catalase activity ( In addition to oxidative stress cytotoxicity, pyocyanin pathogenicity has shown to alter calcium homeostasis and depleting intracellular cAMP and ATP levels ( The effect of GSH in neutralizing epithelial cellular cyto-toxicity has been investigated in this study
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