In the UK, NICE specifically recommends semaglutide (TA875) for adults with a BMI 35 kg/m (or 30 kg/m for certain ethnic groups) who have at least one weight-related comorbidity, with treatment limited to a maximum of 2 years
Curr Med Chem 30(22):24762479 Trevaskis JL, Griffin PS, Wittmer C, Neuschwander-Tetri BA, Brunt EM, Dolman CS, Erickson MR, Napora J, Parkes DG, Roth JD (2012) Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice
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By increasing the activity or number of L-cells producing GLP-1, this approach can potentially improve therapeutic outcomes, reduce reliance on synthetic agonists, and minimize associated side effects
123 Curiously, glucagon has been shown to induce satiety in both human and rat studies, 124 which is surprising as this hormone is released into circulation due to a decrease in plasma levels of nutrients, and thereby it induces the breakdown of stored nutrients so that tissues throughout the body have fuel to generate ATP when needed
