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Research has shown that NEDD4 expression in the kidney and liver is regulated by 20-hydroxyeicosatetraenoic acid through the neddylation modification pathway [55] and that Nedd4-2 activation regulates the ubiquitination modification of renal NBCe1 [56]

Further clinical data are warranted." Abstract Objective: To assess the pharmacokinetics of etravirine once and twice daily without and with a preceding efavirenz intake period in healthy volunteers