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GLP-1s also seem to decrease substance use disorders by affecting dopamine pathways, particularly in alcohol use disorder

Neural progenitor cells derived from lithium responsive and non-responsive bipolar disorder patients exhibit distinct sensitivity to cell death following methamphetamine

In addition to glycemic control, GLP-1 RAs induce significant weight loss, establishing them as foundational therapies in the management of T2DM and obesity (17)

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]