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The ROS cause the mitochondria to swell and disrupt their internal folded membranes, known as cristae, which house the electron transport chain

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Elevated concentrations of metals (such as As, Cd, Cr, Hg, Ni, and Pb) may affect photosynthetic apparatus, electron transport chain and chlorophyll biosynthesis, induce cellular damage, impair cellular redox homeostasis, and finally cause cellular metabolic arrest (Anjum et al., 2010, 2012a

No long term clinical human studies currently exist

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