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Australia also operates the Clinical Trial Exemption (CTX) scheme for situations where TGA pre-evaluation of the trial protocol is desired, though CTX is less commonly used

Fertility and Sterility 2006;86:133643

Recently available satiety-inducing incretin-based medicines are already revolutionising obesity management and greatly improving glycaemic control in type 2 diabetes [7]

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This is crucial for species adaptation because it has been shown that maternal steroid hormones are rapidly metabolized by fetal-placental tissues to shape the fetal brain and modulate neurodevelopment and behavior as an adaptive consequence to the exposure of maternal steroid hormones, and independently of its classical effects mediated by their nuclear steroid hormone receptors (196)