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The GLP-1-induced excitation of orexinergic neurons is a directly postsynaptic effect that may be mediated by sodium-dependent non-specific cationic conductances

Unlike traditional peptide-based agonists that target the extracellular domain, this binding induces a conformational change that triggers potent signaling

Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype

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Concentrations vary widely based on study design, experimental endpoints, and research model selection