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J Neuropathol Exp Neurol 65(6):56270 Booij L et al (2005) The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients

Tryptophan products are subject non-enzyme deamination, at physiological pH, resulting in ,-unsaturated ketone, reactive intermediates 55, which can covalently bind to amino acids, usually His, Cys, or Lys residues in proteins of human lenses, or react with the Cys residue of glutathione (GSH) to form GSH-3OHKynG 54

Why people cycle peptides at all The main rationale is receptor desensitization (also called downregulation or tachyphylaxis)

Microvascular and cardiovascular outcomes according to renal function in patients treated with once-weekly exenatide: insights from the EXSCEL trial