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Nevertheless, LED209 serves as a proof of concept for targeting QseC, allowing inhibition of virulence without directly affecting bacterial growth
CB-839 is a highly potent allosteric inhibitor that completed phase I clinical trials in March 2019 in patients with advanced RCC (NCT02071862) and has in 2020 moved to phase II clinical trials in patients with non-small cell lung cancer (NCT04265534)
NAC supports ongoing production, while glutathione provides an immediate replenishment
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