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GLP-1 Receptor Agonists: Single Agonists in Obesity Treatment Role of GLP-1 in Energy and Glucose Homeostasis Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by enteroendocrine K cells in the proximal small intestine in response to nutrient ingestion

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Although preliminary studies across various metabolic and mental disorders flank these promising findings regarding potential treatments of motivational dysfunction, we also highlight the need to investigate reward phases beyond anticipation to fully capitalize on the potential of gut-based interventions, specifically for mental disorders

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