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The PAM-dependent responses to green bean coffee were three-fold greater than those to dark roasted coffee, consistent with 7 receptor activation by choline, a component of coffee that is partially degraded in the roasting process

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Holton is a lifelong creative with a grab-bag of eclectic experiences & education to rummage for inspiration: he has produced films for big & small formats, penned articles for travel magazines, covered screenplays for Hollywood studios, & performed on stage for live theatre audiences