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Expert Opinion Drug Metab Toxicol 5(2):211223 Jamei M, Dickinson GL, Rostami-Hodjegan A (2009) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of bottom-up vs top-down recognition of covariates

These metabolites, which circumvent the toxic constituents of smoke, primarily exhibit antioxidant, anti-lipid production, pro-lipid oxidation, pro-insulin sensitivity, anti-inflammatory, anti-apoptotic, and antimicrobial properties

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