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A manufacturer must submit a PMTA and receive a PMTA marketing authorization order to legally market a new tobacco product that is not substantially equivalent to a predicate tobacco product or exempt from substantial equivalence

Phil Chamberlain, deputy director of the Tobacco Control Research Group at Bath University, said the campaigns were an opaque attempt to shape public opinion by lobbyists whose views echoed those of the industry

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Similar leukocytosis has been observed in other studies 25,26