As a systematic review by the Cochrane Library noted: The small number of trials, low event rates and wide confidence intervals around the estimates mean that our confidence in the result is rated low. For example, there were weaknesses in the randomized trials
These limitations include imprecision in measurement of e-cigarette exposure, inclusion of smokers not using e-cigarettes to quit, limited adjustment for confounding factors, and variable outcome measures of cessation (Levy et al., 2017)
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