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Human beings and laboratory animals metabolise NNK into NNAL and NNKs glucuronides (NNAL-Glucs).17 These compounds are excreted in the urine, and the total amount, known as total NNAL, is a practical and widely used biomarker of NNK exposure.59 The carcinogenic properties of NNAL are quite similar to those of NNK, whereas NNAL-Glucs are detoxi cation products.17 The NNAL biomarker has been extensively used in studies of NNK exposure in smokers, smokeless tobacco users, and non-smokers exposed to involuntary tobacco smoke.59 Advantages of this biomarker include its high reliability and speci city to tobacco products

Juul Labs Inc., based in San Francisco, said it had initially hesitated to accept the investment from Altria

He can see his country from that distance

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