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The sample size re-estimation, afforded by the adaptive design, indicated that the number of additional participants required to detect the expected effect was not considered feasible within available resources, so the study was terminated at that stage

The studies included a nationally representative sample of adult smokers, a sample of Appalachian adult smokers, and a national sample of teens who were smokers or who were at high risk of taking up smoking

[15] Estimates put Chinese counterfeit production as high as 400 billion cigarettes per year to meet international demand.[16] Because of the enormous volume of product that ships into U.S

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The signs showed them what smoking can do to their bodies