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The EDS Leiden Open Variation Database (LOVD) [27] contains approximately 200 and 60 unique COL5A1 and COL5A2 pathogenic variants, respectively

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Children with parents who smoke face a higher risk of stunting. Tobaccos impact on child growth Children whose parents smoke face a higher risk of stunted growth, with risks increasing the more they are exposed

One particular study shows the 2mg strength nicotine gum had a 16% efficacy in high dependence smokers (2) - those craving a cigarette when they wake up - meaning 16% of the subjects had stopped smoking at one year

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