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it does not prove a single shelf-life number for every retail cartridge

However, an American Thoracic Society (ATS) systematic review of eight studies demonstrated that extended use of a controller therapy for greater than 12 weeks leads to significantly higher sustained quit rates and lower relapse rates compared with standard use of six to 12 weeks, with a number needed to treat (NNT) of 19 for one additional patient achieving abstinence at one year