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rsfMRI images were acquired using a T2*-weighted gradient echo echo-planar-imaging (EPI) sequence with following parameters: TR = 2 s, TE = 30 ms, slice thickness = 3.3 mm, 35 slices, FOV = 220 220 mm 2 , and matrix = 64 64

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Patients with persistent systemic inflammation have a higher mortality rate and more frequent episodes of acute exacerbation ( Several studies have identified the presence of potentially pathogenic microorganisms (PPM) in the lower respiratory tract of patients with stable COPD, which may lead to systemic inflammation and increased serum C-reactive protein (CRP), interleukin-8 (IL-8) levels and plasma fibrinogen (FIB) (26, 94, 95)