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Impact of DPP4 Inhibition on Pancreatic Islets Accumulating in vitro and pre-clinical data show that DPP4 inhibition has beneficial effects on T2DM induced -cell dysfunction and apoptosis
Collectively, these findings highlight cotadutides dual benefits for glycemic control and liver health, supporting its further development for T2D, obesity, and NASH treatment [85]
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Ziltivekimab, a new monoclonal antibody directed against IL-6, has been specifically designed for patients with atherosclerosis and high cardiovascular risk and is being evaluated both in patients with atherosclerosis and CKD and in patients with HFpEF [20,21,22]
Overall, GLP-1 RAs showed a trend toward improvements across most disease outcomes
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