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IGH typically occurs in people with lighter skin tones over the age of 40, and becomes increasingly common with age

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Additionally, overexpression of alpha-synuclein increases the phosphorylation of NMDARs, thereby increasing the expression of NR1 and NR2B subunits and increasing the sensitivity of NMDARs to glutamate excitotoxicity (Yang et al., 2016)

Chen Y, Wang W, Morgan MP, Robson T, Annett S (2023) Obesity, non-alcoholic fatty liver disease and hepatocellular carcinoma: current status and therapeutic targets